Set in early 1900s New York at the Knickerbocker Hospital, this gripping medical drama follows Dr. John Thackery, a brilliant but deeply flawed surgeon pioneering groundbreaking surgical techniques in an era before antibiotics and modern medicine. The series captures the desperation of a teaching hospital where mortality rates are catastrophic, while exploring Thackery's internal struggle with cocaine addiction and his complex relationships with colleagues and staff. It's a visceral, atmospheric exploration of ambition, innovation, and the human cost of medical progress.